Tissue-level cytoprotection
نویسندگان
چکیده
منابع مشابه
Gastric cytoprotection.
The term 'cytoprotection' means protection against gastric mucosal injury by a mechanism other than inhibition or neutralisation of gastric acid. Several mechanisms of gastric cytoprotection have been proposed like increased mucus and bicarbonate secretion, strengthening of gastric mucosal barrier, increased gastric mucosal blood flow, decreased gastric motility, increased formation of prostagl...
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Prostaglandins (PGs) are widely distributed throughout the gastrointestinal tract and affect a variety of gastrointestinal functions. The observation that PGs of the E and A series are potent inhibitors of gastric acid secretion and that PGs, especially the E compounds, are released into the gastric lumen during vagal or gastrin stimulation suggests a possible physiological role for these agent...
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1 Inserm UMR-S 769, LabEx LERMIT, Châtenay-Malabry, F-92296, France 2University Paris-Sud, Châtenay-Malabry, F-92296, France 3 Inserm UMR 676, Hôspital Robert Debré, F-75019 Paris, France 4Faculté de Médecine Denis Diderot, Université Paris 7, IFR02, F-75019 Paris, France 5Faculty of Medicine, Institute of Reproductive and Developmental Biology, Hammersmith Hospital, Imperial College London, Lo...
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Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is known to play a central role in lipid metabolism and insulin sensitivity as well as inflammation and cell proliferation. According to the results obtained from studies on several animal models of gastrointestinal inflammation, PPARγ has been implicated in the regulation of the immune response, particularly inflam...
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Development of acute graft-versus-host disease (aGVHD) predisposes to chronic GVHD with autoimmune manifestations. A characteristic of experimental aGVHD is the de novo generation of autoreactive T cells. Central tolerance is dependent on the intrathymic expression of tissue-restricted peripheral self-antigens (TRA), which is in mature medullary thymic epithelial cells (mTEC(high)) partly contr...
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ژورنال
عنوان ژورنال: Cell Stress & Chaperones
سال: 2000
ISSN: 1355-8145,1466-1268
DOI: 10.1379/1466-1268(2000)005<0412:tlc>2.0.co;2